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Allan-Herndon-Dudley syndrome was among the first of the X-linked mental retardation syndromes to be described in and among the first to be regionally mapped on the X chromosome in Six large families with the syndrome have been identified, and linkage studies have placed the gene locus in Xq Mutations in the monocarboxylate transporter 8 gene MCT8 have been found in Koreatown massage Dagenham of the six families. One essential function of the protein encoded by this gene appears to be the transport of triiodothyronine into neurons. Abnormal transporter function is reflected in elevated free triiodothyronine and lowered free thyroxine levels in Torquay professional singles blood.
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